Tuesday, November 25, 2014

Disorders of the Endocrine System - Answers and Rationale

1.     Answer: A
A bladder retraining program, such as use of a toileting schedule, may be helpful to clients experiencing urinary incontinence. 

B. A Foley catheter should be used only when necessary because of the risk of infection. 

C&D. Use of the diaper or pad is the least acceptable alternative because of the risk of skin breakdown.

2.     Answer: B
Emergency treatment for acute adrenal insufficiency (addisonian crisis) is I.V. infusion of hydrocortisone and saline solution. The client is usually given a dose containing hydrocortisone 100 mg I.V. in normal saline every 6 hours until the client's blood pressure returns to normal. 

A. Insulin isn't indicated in this situation because adrenal insufficiency is usually associated with hypoglycemia. 

C. Potassium isn't indicated because these clients are usually hyperkalemic. 

D.The client needs normal — not hypotonic — saline solution.

3.     Answer: D
Chlorpropamide (Diabenese) is an oral hypoglycemic agent given to reduce the serum glucose level and the signs and symptoms of hyperglycemia. Therefore a decrease in polyuria and polyphagia and symptoms of hyperglycemia would denote a beneficial response to chlorpropamide. Laboratory values also are used to assess the client’s response to treatment. A fasting blood glucose level of 110 mg/dL is within normal limits. However, a glycosylated hemoglobin of 10% denotes poor glycemic control.

4.     A client with aldosteronism is being treated with spironolactone (Aldactone). Which of the following indicates to the nurse that the medication is effective?

A.     A decrease in blood pressure
B.     A decrease in sodium excretion
C.    A decrease in plasma potassium
D.    A decrease in body metabolism

Answer: A
Spironolactone is a potassium-sparing diuretic that antagonizes the effect of aldosterone and decreases circulating volume by inhibiting tubular reabsorption of sodium and water. Thus spironolactone produces a decrease in blood pressure by increasing the excretion of sodium and water. Potassium is retained. Spironolactone has no effect on body metabolism.


5.     Answer: A
Divalproex sodium (Depakote), an anticonvulsant, can cause a potentially fatal hapatotoxicity. The nurse should instruct the client about the importance of monitoring the results of liver function studies and ammonia levels. Options B, C, and D are not studies that are required with the use of this medication.

6.     Answer: D
An elevated temperature may indicate infection. Infection is a leading cause of hyperglycemic hyperosmolar nonketotic syndrome or diabetic ketoacidosis. The other findings noted in the question are within normal limits.

7.     Answer: A
Diabetic ketoacidosis is marked by the presence of excessive ketone bodies. Because of the acidosis, the pH and serum bicarbonate level would decrease. Hyponatremia is not related to diabetic ketoacidosis.

8.    Answer: C
The client with Cushing’s syndrome and a nursing diagnosis of Excess Fluid Volume should be maintained on a high-potassium and low-sodium diet. Decreased sodium intake decreases renal retention of sodium and water. Options A, B, and D are appropriate interventions for the client with a nursing diagnosis of excess fluid volume.

9.    Answer: B
A quick check of the blood glucose level will confirm whether the client is hypoglycemic.

A. This is inaccurate and does not reflect the present status.

C. Although this might be appropriate to counter hypoglycemia, it does not determine whether the client is being hypoglycemic or is being manipulating.

D. Although this might be appropriate to counter hypoglycemia, it does not determine whether the client is being hypoglycemic or is being manipulating.

10.   Answer: A
The client who has undergone a thyroidectomy is at risk for developing hypocalcemia from inadvertent removal or damage to the parathyroid gland. The client with hypocalcemia will exhibit a positive Chvostek's sign (facial muscle contraction when the facial nerve in front of the ear is tapped) and a positive Trousseau's sign (carpal spasm when a blood pressure cuff is inflated for a few minutes). These signs aren't present with hypercalcemia, hypokalemia, or hyperkalemia.

11.   Answer: B
Graves' disease, an autoimmune disease causing hyperthyroidism, is most prevalent in middle-age females. In thyroiditis, there is a low (≤2%) radioactive iodine uptake. In Hashimoto's thyroiditis, the most common form of hypothyroidism, TSH levels would be high and thyroid hormone levels low. Multinodular goiter will show an uptake in the high-normal range (3% to 10%).

12.   Answer: A
Renal and cardiac complications will occur if the hypertension caused by the tumor is not arrested. 

B. An aldosteronoma is a benign tumor; metastasis is not possible. 

C. This is not true; surgery is required to remove the tumor. 

D. Drugs are not used; the tumor must be removed.

13.   Answer: D
Adequate dietary iodine is needed to produce thyronine (T3) and thyroxine (T4). The other requirements for adequate T3 and T4 production are not intact and a functional hypothalamic-pituitary-thyroid feedback system. Options A, B, and C are not related directly to the function of T3 and T4.


14.   Answer: D
The client should be instructed that insulin injection sited should be rotated within one anatomical area before moving to another area. This rotation process promotes uniform absorption of insulin and reduces the chances of irritation. Options A, B, and C are not associated with the condition (skin leakage of insulin) presented in the question.

15.   Answer: D
The client with Addison’s disease will require life long replacement of adrenal hormones. The medications must be taken daily and an alternate route of administration must be used if the client cannot take oral medications for any reason, such as nausea and vomiting. Additional doses of glucocorticoids will be needed during times of stress. The nurse must emphasize that the client must call the physician to obtain a prescription for a dosage increase when experiencing stressful situations. Abrupt withdrawal of this medication can result in addisonian crisis. Although side effects are not severe at lower doses, side effects occur with long-term glucocorticoid administration. To stop taking the medication without first consulting the physician is unsafe.

16.   Answer: B
Calcitonin can lower plasma calcium levels in clients with hyperparathyroidism. The therapeutic effect in this client situation would be a reduction in serum calcium levels. Options A, C, and D are incorrect outcome criteria.

17.  Answer: D
A client in ketoacidosis receives normal saline as a solution because it is isotonic and does not contain glucose. The client receives this solution until the blood glucose level approaches the normal range. The rate, or units given per hour, is based on the child's weight.

A. A child in ketoacidosis has elevated blood glucose levels. A 2.5% dextrose is not used because its glucose content would only serve to further elevate the child's glucose levels. 

B. A child in ketoacidosis has elevated blood glucose levels. A 5% dextrose solution is not used because its glucose content would only serve to further elevate the child's glucose levels. 

C. A 0.45% saline solution would not be used. Physicians typically order a 0.9% saline solution because it is isotonic and more nearly matches the concentration of a child's blood. 

18.  Answer: A
Once the excessive secretion of aldosterone is stopped, the BP gradually drops to a near normal level. 

B. The BP drops gradually; it does not rise. 

C. The BP will only fluctuate if the hypervolemia is overcorrected, causing hypovolemia; this is not expected. 

D. The BP drops gradually in response to decreasing serum corticosteroid levels; a rapid drop immediately following surgery may indicate hemorrhage.

19.  Answer: A
Antidiuretic hormone is secreted by the posterior pituitary gland. The other hormone stored in the posterior pituitary gland is oxytocin. Antidiuretic hormone and oxytocin are produced by the hypothalamus and stored in the posterior pituitary gland. These hormones are released as needed into the bloodstream for use. The anterior pituitary gland produces growth hormone, follicle-stimulating hormone, and luteinizing hormone.

20.   Answer: B
Shakiness is a sign of hypoglycemia and would indicate the need for food or glucose. A fruity breath odor, blurred vision, and polyuria are signs of hyperglycemia.

21.   Answer: A
The client should be instructed to avoid exercise at peak insulin time because at this time a hypoglycemic reaction is likely to occur. If the client performs exercises at this time, the nurse should instruct the client to eat an hour before the exercise and drink a carbohydrate liquid. Options B, C, and D are correct statements regarding exercise, insulin, and diabetic control.

22.   Answer: A
Addisonian crisis results in hyperkalemia; therefore, administering potassium chloride is contraindicated. Because the client will be hyponatremic, normal saline solution is indicated. Hydrocortisone and fludrocortisone are both useful in replacing deficient adrenal cortex hormones.

23.   Answer: B
The nurse teaches the client to avoid tension on the suture line; otherwise, hemorrhage may develop. One way of reducing incisional tension is to teach the client how to support the neck when coughing or being repositioned. Likewise, during the postoperative period, the client should avoid any unnecessary movement of the neck. That is why sandbags and pillows frequently are used to support the head and neck. Removal of the thyroid does not necessarily mean that the client will be taking antithyroid medications postoperatively. If a client experiences tingling in the fingers, toes, and lips, it is probably due to injury to the parathyroid gland during surgery, resulting on hypocalcemia. These signs and symptoms need to be reported immediately.

24.   Answer: D
Hyperthyroidism is manifested clinically by goiter (increase in the size of the thyroid gland) and exothalmos (bulging eyeballs). Clinical manifestations also include nervousness, fatigue, weight loss, muscle cramps, and heat intolerance. Other signs found in this disorder include tachycardia, shortness of breath, excessive sweating, fine muscle tremors, thin silky hair and skin, infrequent blinking, and a staring appearance.

25.  Answer: D
Thyroid crisis is severe hyperthyroidism; excessive amounts of thyroxine increase the metabolic rate, thereby raising the pulse and temperature.

A. During thyroid crisis there is usually no increase in the difference between the apical and peripheral pulse rates (pulse deficit). 

B. The blood pressure will rise to meet the oxygen demand caused by the increased metabolic rate during thyroid crisis. 

C. Because of the increased metabolic rate, the pulse and respiratory rates increase to meet the body's oxygen needs. 

26.   Answer: B
The client is exhibiting signs and symptoms of hypocalcemia, which occurs with accidental removal of the parathyroids; calcium gluconate is the treatment of choice.

A. This is prescribed for hyperthyroidism because it inhibits the release of thyroid hormones. 

C. This is prescribed for hypomagnesemia or to prevent convulsions in eclampsia or preeclampsia. 

D. This is prescribed for hypokalemia.

27.   Answer: B
Management of children with early morning hyperglycemia depends on whether the hyperglycemia is due to insulin-waning, a progressive rise in blood glucose throughout the day, or rebound hyperglycemia (Somogyi effect; an increase in blood sugar glucose at bedtime, a drop at about 2:00 AM, then a rebound rise early in the morning). Information about the child's blood glucose levels would provide clues to determine which event is occurring.

A. Telling the mother that this is normal is inappropriate. Management of children with early morning hyperglycemia depends on whether the hyperglycemia is due to insulin-waning, a progressive rise in blood glucose throughout the day, or rebound hyperglycemia (Somogyi effect; an increase in blood sugar glucose at bedtime, a drop at about 2:00 AM, then a rebound rise early in the morning). Information about the child's blood glucose levels would provide clues to determine which event is occurring.  

C. Early morning hyperglycemia is not unusual nor is it an emergency situation. Management of children with early morning hyperglycemia depends on whether the hyperglycemia is due to insulin-waning, a progressive rise in blood glucose throughout the day, or rebound hyperglycemia (Somogyi effect; an increase in blood sugar glucose at bedtime, a drop at about 2:00 AM, then a rebound rise early in the morning). Information about the child's blood glucose levels would provide clues to determine which event is occurring. 

D. Although questioning the mother to gain more information is appropriate, asking her specifically about avoiding sweets may imply the mother is at fault for not monitoring the child's intake closely. Additionally, carbohydrates, not sweets, are implicated in diabetes. Management of children with early morning hyperglycemia depends on whether the hyperglycemia is due to insulin-waning, a progressive rise in blood glucose throughout the day, or rebound hyperglycemia (Somogyi effect; an increase in blood sugar glucose at bedtime, a drop at about 2:00 AM, then a rebound rise early in the morning). Information about the child's blood glucose levels would provide clues to determine which event is occurring.

28.   Answer: C
The hypothalamus exerts influence on the anterior and posterior pituitary gland. Abnormalities can result in excess or deficit of substances normally mediated by the pituitary. Antidiuretic hormone could be affected by disease of the hypothalamus because the hypothalamus produces antidiuretic hormone and stores it in the posterior pituitary gland. The adrenal cortex is responsible for the production of glucocorticoids and mineralocorticoids. The pineal gland is responsible for melatonin production.

29.   Answer: D 
Diabinese is a sulfonamide, a sulfur-based drug, used to treat type 2 diabetes. It would be contraindicated in a patient with an allergy to sulfur. Therefore, the physician should be notified. 

A. Aspirin is a non-steroidal anti-inflammatory drug. It is a salicylate and not related to sulfur-based medications. 

B. Penicillin is a broad-spectrum antibiotic and is frequently the next choice of drug to treat bacterial infections when the patient is allergic to sulfur. 

C. Iodine is a nonmetallic element that aids in the development of the thyroid gland. It is used to treat goiter.

30.   Answer: B
Ketones are a by-product of fat metabolism. When this process occurs to extreme, this process is called ketoacidosis. Options A, C, and Dare incorrect.

31.   Answer: C
After a thyroidectomy the thyroxine output is usually inadequate to maintain an appropriate metabolic rate.

A. Hypothyroidism is a decrease in thyroid functioning, not a slowing of the entire body's functions. 

B. In hypothyroidism the level of thyroid-stimulating hormone (TSH) from the pituitary is usually increased. 

D. Atrophy of the thyroid tissue remaining after surgery does not occur.

32.   Answer: D
With long- term use Phenytoin can cause gingival hyperplasia, so it is essential that the client understand how to provide proper oral hygiene. 

A.  Phenytoin does not lead to the development of diabetes, but it can affect the diabetics' blood glucose levels and require adjustment of their hypoglycemic agents. 

B. The client cannot substitute various brands of phenytoin because they are not bioequivalent. 

C. It is not necessary for the client to take potassium supplements.

33.   Answer: C
Wound healing in a client with diabetes will be delayed. Providing the client with a time frame could give the client false information.

34.   Answer: A
Physical symptoms can interfere with an individual’s ability to learn and also can indicate to the teacher that the learner lacks motivation to learn, if the symptoms repeatedly recur when teaching is initiated. Options B, C, and Didentify active client participation in learning.

35.  Answer: C
Small amounts of fluid may be tolerated even when vomiting is present. The nurse should encourage liquids containing glucose and electrolytes every hour. Options A, B, and D will not provide the adequate intake needed by the client with diabetes mellitus.

36.  Answer: A
Glucagon, produced by the alpha cells in the islets of Langerhans, is an insulin antagonist. It mobilizes glycogen storage in the liver, leading to an increased blood glucose level. 

B. This stimulates an increase in blood glucose, not glycogen. 

C. Glucagon does not compete with insulin; it promotes the conversion of glycogen to glucose. 

D. Glucagon is not a glucose substitute.

37.   Answer: C
Because the client in addisonian crisis is unstable, vital signs and fluid and electrolyte balance should be assessed every 30 minutes until he's stable. Daily weights are sufficient when assessing the client's condition. The client shouldn't have ketones in his urine, so there is no need to assess the urine for their presence. Oral hydrocortisone isn't administered during the first 24 hours in severe adrenal insufficiency.

38.   Answer: C
Oral calcium supplements need to be administered with food to enhance absorption and to decrease gastrointestinal irritation. Options A, B, and Dare unrelated to oral calcium therapy.

39.   Answer: A
Regular insulin is rapid acting (30 to 60 minutes) and is used to meet a client's immediate insulin needs. 

B. This is an intermediate-acting insulin, which has an onset of 1 to 2 1/2 hours; in diabetic acidosis the individual needs rapid-acting insulin. 

C. This is an intermediate-acting insulin, which has an onset of 1 to 2 hours; in diabetic acidosis the individual needs rapid-acting insulin. 

D. This is a long-acting insulin, with an onset of 4 to 8 hours and a peak of 10 to 30 hours.

40.   Answer: C
During the postoperative period, the nurse carefully observes the client for signs of hemorrhage, which causes swelling and compression of adjacent tissue. Laryngeal stridor is a harsh, high-pitched sound heard on inspiration and expiration; stridor is caused by compression of the trachea, leading to respiratory distress. Stridor is an acute emergency situation that requires immediate attention to avoid complete obstruction of the airway. Options A, B, and D do not identify signs of a life-threatening complication.

41.   Answer: B
Bed-wetting in a previously continent child is a sign suggesting hyperglycemia. The enuresis is due to polyuria, one of the cardinal signs of insulin-dependent diabetes mellitus. Other signs include polydipsia (excessive thirst) and polyphagia (excessive hunger). 

A. Typically the child with hyperglycemia secondary to insulin-dependent diabetes is slightly lethargic. 

C. Although the child with insulin-dependent diabetes experiences excessive hunger, the child loses weight even though he or she is eating more. 

D. Another cardinal sign of insulin-dependent diabetes is polyphagia, or excessive hunger. The child eats more even though he loses weight. Excessive thirst is also a typical sign.

42.   Answer: C
The causes of type 1 diabetes mellitus include an involvement of genetic factors, specifically the presence of the human leukocyte antigen. This factor is found in many clients with type 1 diabetes mellitus. Autoimmune factors and viruses also are thought to play a role in its development. The problem with type 1 diabetes mellitus is the destruction of the beta cells. Type 1 diabetes mellitus is not due to a primary failure of glucagon secretion.

43.   Answer: D
The pancreas produces endocrine and exocrine secretions as part of its normal function. The organ secretes insulin as a key endocrine hormone to regulate the blood glucose level. Other pancreatic endocrine hormones are glucagon, and somatostatin. The exocrine pancreas produces digestive enzymes such as amylase, lipase, and trypsin.

44.   Answer: A
PTH stimulates the kidneys to reabsorb calcium and excrete phosphate and converts vitamin D to its active form: 1,25-dihydroxyvitamin D. PTH doesn't have a role in the metabolism of vitamin E.

45.   Answer: C
Diabetes mellitus can lead to metabolic acidosis. When the body does not have sufficient circulating insulin, the blood glucose level rises. At the same time, the cells of the body use all available glucose. The body then breaks down glycogen and fat for fuel. The by-products of fat metabolism are acidotic and can lead to the condition known as diabetic ketoacidosis. Options A, B, and D are incorrect.

46.   Answer: B
Polydipsia and polyuria are classic symptoms of diabetes insipidus. The urine is pale, and the specific gravity is low. Anorexia and weight loss occur. Options A and Dare not specific to this disorder.

47.   Answer: C
NPH is intermediate-acting insulin. The onset of action of NPH insulin is 1 to 2 hours, it peaks in 6 to 14 hours, and its duration of action is 24 hours. Hypoglycemic reactions most likely occur during peak time.

48.   Answer: C
Bacon is a component of the fat group in the exchange system. One teaspoon of butter is equal to 1 tsp margarine, 1 tsp of any oil, 1 tbs of salad dressing, 1 strip of bacon, 5 large olives, or 10 whole peanuts.

49.   Answer: B
Clients with type 2 diabetes mellitus have decreased or impaired insulin secretion. Oral hypoglycemic agents are given to these clients to facilitate glucose utilization. Insulin injections may be given during times of stress-induced hyperglycemia. Oral insulin is not available because of the breakdown of the insulin by digestion. Options A, C, and D are incorrect.

50.   Answer: A
There is a greater incidence of both gestational diabetes and preexisting diabetes among women older than 35 years. In addition, clients of Native American and Hispanic descent have a greater incidence of gestational diabetes than the general population. 

B. The client does not present symptoms that would warrant testing of chorionic villi. 

C. The client does not present symptoms that would warrant a urine culture and sensitivity test. 

D. The client does not present symptoms that would warrant testing for hepatitis D.

51.   Answer: A
The glycosylated hemoglobin measures the amount of glucose that has become permanently bound to the red blood cells from circulating glucose. The glycosylated hemoglobin in a diabetic client with good control will be 7.5% or less. Elevations in blood glucose will cause elevations in the amount glycosylation. Elevations indicated continued need for teaching related to prevention of hyperglycemic episodes.

52.   Answer: C
Regular insulin, which is a short-acting insulin, has an onset of 15 to 30 minutes and a peak of 2 to 4 hours. Because the nurse gave the insulin at 2 p.m., the expected onset would be from 2:15 p.m. to 2:30 p.m. and the peak from 4 p.m. to 6 p.m.

53.  Answer: B
Hypercalcemia is the hallmark of hyperparathyroidism. Elevated serum calcium levels produce osmotic diuresis and thus polyuria. The diuresis leads to dehydration (weight loss rather than weight gain). Options A and C are gastrointestinal symptoms and are not associated with the common gastrointestinal symptoms typical of hyperparathyroidism (nausea, vomiting, anorexia, constipation).

54.  Answer: A
Foods high in dietary fiber are recommended by the American Diabetes Association because they tend to blunt the rise in blood glucose levels after meals. Dietary fiber is the part of food not broken down and absorbed during digestion. Most fibers come from plants; good sources include whole grains, legumes, vegetables, fruits, and nuts.

B. Dairy products are poor sources of fiber and meats. 

C. Foods fortified with vitamins are satisfactory if they also contain fiber. However, many foods fortified with vitamins contain either no dietary fiber (such as fortified milk) or little fiber (such as products fortified with vitamins but made with refined grains). 

D. Meats are poor sources of fiber.

55.   Answer: B
Symptoms of hypoglycemia include tachycardia, shakiness, and cool clammy skin. Options A, C, and D are not symptoms of hypoglycemia.

56.   Answer: C
Snacks are included in the diabetic diet to offset periods of peak insulin action. Because of the lack of pancreatic functioning, the child does not receive differing amounts of insulin in response to the glucose level in the bloodstream. The child with diabetes mellitus is given insulin at specific times; dietary intake must be matched to the insulin peaks and troughs. 

A. The risk of hyperglycemia is not eliminated through regular snacks, although spreading the calories throughout the day may help the child achieve a more steady blood glucose level. 

B. Snacks are not used to decrease the amount of food eaten at meals. 

D. Snacks are not used to offset hunger for sweets.

57.   Answer: B
Strenous exercise, such as running, should be avoided if the adolescent's blood glucose level is 240 ng/dLmg/dL or above. When insulin levels are not adequate, the cells cannot receive glucose even though the blood glucose level is high. With low insulin levels, glucagons acts to increase hepatic glucose production thus raising the blood glucose level, which cannot be used at the muscle site. 

A. Vigorous muscle contraction increases local blood flow and absorption of insulin injected into that area, placing the adolescent at risk for hypoglycemia. This action should be avoided. 

C. Because exercise decreases blood glucose levels, snacks would be given before strenuous exercise to prevent hypoglycemia. Taking extra insulin and the effects of exercise place the adolescent at high risk for hypoglycemia. 

D. Snacks are used before strenuous exercise to prevent hypoglycemia. If the adolescent cannot tolerate the extra needed food, insulin dosage may be reduced but only on the advice of the physician.

58.   Answer: C
The glycosylated Hb test provides an objective measure of glycemic control over a 3-month period. The test helps identify trends or practices that impair glycemic control, and it doesn't require a fasting period before blood is drawn. The nurse can't conclude that the result occurs from poor dietary management or inadequate insulin coverage.

59.   Answer: C
The client's trouble stems from perceptual difficulties; the preset syringe removes the need to differentiate between 24 and 42 units. 

A. This would not solve the transposition of the numbers; the problem is not caused by the inability to see the numbers but by the child's perception of them. 

B&D. This would not solve the transposition of the numbers. 

60.   Answer: B
Cushing’s syndrome is characterized by an excess of cortisol, a glucocorticoid. Glucocorticoids are produced by the adrenal cortex. Epinephrine and norepinephrine are produced by the adrenal medulla. Calcium is unrelated to this disorder.

61.   Answer: B
Headache is common after the procedure, but neck stiffness, especially on flexion, and pain should be reported because they signal meningeal irritation. The nurse also monitors the client for allergic reactions to the dye such as confusion, dizziness, tremors, and hallucinations. Feelings of fatigue may be normal, and back discomfort may be due to the positions required for the procedure.

62.  Answer: A
Regular insulin administered intravenously is the treatment choice for diabetic ketoacidosis (DKA). This short-acting insulin is the only insulin that can be given intravenously and is titrated to the client’s blood glucose levels. NPH insulin is intermediate-acting insulin and thus is not appropriate for treatment of DKA. Glucagon is used treat hypoglycemia because it increases blood glucose levels, and glyburide is an oral hypoglycemic agent used to treat type 2 diabetes mellitus. Both of these agents are also inappropriate.

63.   Answer: B
With over activity of the thyroid gland, metabolism is increased, including fat metabolism. The increased metabolism leads to decreased levels of fat in the bloodstream, including cholesterol, and decreased body fat stores. Weight loss occurs as a result of the increased metabolic activity. Glucose tolerance is decreased, and the client experiences hyperglycemia. Although the client has an increased appetite, food intake does not meet energy demands, and nutritional deficiencies can develop.

64.   Answer: A
Digital subtraction is a radiographic method to study the blood vessels. The nurse should explain to the client that the test provides information about the blood vessels. Options B, C, and Dare incorrect.

65.   Answer: B
Levothyroxine (Synthroid) is a synthetic thyroid hormone that increases cellular metabolism. Levothyroxine should be given in the morning in a single dose to prevent sleeplessness and should be given at the same time each day to maintain an adequate drug level.

66.   Answer: B
The most effective and accurate measure for testing blood glucose is to test the level before each meal and at bedtime. Checking the level after the meal will provide an inaccurate assessment of diabetic control. Checking the level once daily will not provide enough data related to controlling the diabetes mellitus.

67.   Answer: D
Insulin dosages not be adjusted and should not be increased before unusual exercise. If acetone is found in the urine, it possibly may indicate the need for additional insulin. To minimize the discomfort associated with insulin injections, insulin should be administered at room temperature. Injection sites should be rotated systematically from one area to another.

68.   Answer: B
Decreased blood glucose levels trigger autonomic nervous system symptoms such as nervousness, irritability, and tremors. Hot, dry skin accompanies hyperglycemia. Anorexia and muscle cramps are unrelated to hypoglycemia.

69.   Answer: C
Clients with diabetes mellitus are instructed to make adjustments in their total daily intake to plan for meals at restaurants or parties. Some useful strategies include ordering a half portion, salads with dressing on the side, fresh fruit for dessert, and baked or steamed entrees. Clients are not instructed to skip meals or to increase their prescribed insulin dosage.

70.   Answer: C
Foot soaks macerate the skin and increase the risk for breaks. Water-soluble lotions are recommended to moisturize the feet. Nail files are preferred over nail clippers or scissors. Antiperspirants may be used when foot perspiration exists.

71.  Answer: D
Hypocalcemia can develop after thyroidectomy if the parathyroid glands are removed accidentally in during surgery. Manifestations develop 1 to 7 days after surgery. If the client develops numbness and tingling around the mouth, fingertips, or toes; muscle spasms; or twitching, the physician is notified immediately. Calcium gluconate should be kept at the bed side.

72.   Answer: B
Epinephrine and norepinephrine are produced by the adrenal medulla. The other substances listed (cortisol, aldosterone, and the androgens) are produces by the adrenal cortex.

73.  Answer: A
When a client is scheduled for a fasting blood glucose level drawn, the client should not eat or drink anything except water after midnight. This restriction is needed to ensure accurate test results, which form the basis for adjustments or continuance of treatment. Options B, C, and D are inaccurate, and the client should not consume these items before the test.

74.   Answer: A
Following thyroidectomy, the nurse assesses the client for signs of hypocalcemia and tetany. Early signs include tingling around the mouth and in the fingertips, muscle twitching or spasms, palpitations or dysrhythmias, and a positive Chvostek’s and Trousseau’s sign. Options B, C, and D are not signs of hypocalcemia.

75.   Answer: B
The nurse should instruct the client with Cushing’s syndrome to take the medications exactly as prescribed. The nurse should emphasize the importance of continuing medications, consulting with the physician before purchasing any over-the-counter medications, and maintaining regular outpatient follow-up care. The nurse also should instruct the client about the signs and symptoms of hypoadrenalism and hyperadrenalism.

76.   Answer: D
Discharge instructions for the client hospitalized for hyperthermia includes prevention of heat-related disorders, increased fluid intake for 24 hours, self-monitoring of voiding, and the importance of staying in cool environment and resting.

77.   Answer: C
Eight- to 10-year-olds are developmentally ready to begin to give their own injections with adult supervision. Their fine motor skills are developed enough to accomplish this skill. 

A. Beginning to recognize symptoms of hypoglycemia is appropriate for 4- to 6-year-olds because of their beginning ability to verbalize how they feel. 

B. Measuring insulin accurately in a syringe is more appropriate for 10- to 12-year-olds who have better fine motor skills. 

D. Because of the complexity of disease management, assuming responsibility for self-care is appropriate for an older adolescent.

78.   Answer: D
Expected outcomes for this nursing diagnosis in an unconscious client include stable weight, intake equaling output, evidence of wound healing, and normal blood urea nitrogen, total protein, and hemoglobin levels. The only abnormal finding is the protein level.

79.   Answer: C
With chronic high circulating blood glucose levels, some glucose binds irreversibly onto the red blood cells and remains there for the life of the red blood cells. The average life span of a red blood cell is 120 days. The measurement of glycosylated hemoglobin (HbA 1c), which detects glucose binding on the red blood cell membrane, is expressed as a percent. One of the problems with diabetes is that there may be an inability of muscle and adipose cells to transport glucose across cell membranes. Glucose does not bind onto platelets in diabetes mellitus.


80.   Answer: C
Desired outcomes for nursing interventions to prevent cold discomfort and in the development of accidental hypothermia include the following: hands and limbs are warm, body is relaxed and not curled, body temperature is greater than 97°F, the client is not shivering, and the client has no complaints of feeling cold.

81.   Answer: A
Prednisone may decrease the effect of oral hypoglycemics, insulin, diuretics, and potassium supplements. Options B, a B- blocker, and C, a monoamine oxidase inhibitor, have their own intrinsic hypoglycemic activity. Option D decreases urinary excretion of sulfonylurea agents, causing increased levels of the oral agent, which lead to hypoglycemia.

82.   Answer: B
A high-complex-carbohydrate and high-protein diet will be prescribed for the client with Addison’s disease. To prevent excess fluid and sodium loss, the client is instructed to maintain a normal salt intake daily (3 g) and to decrease salt intake during hot weather, before strenuous exercise, and in response to fever, vomiting, or diarrhea.

83.   Answer: A
When a client with diabetes mellitus is unable to eat normally because of illness, the client still should take the prescribed insulin or oral medication. The client should consume additional fluids and should notify the physician. The client should monitor the blood glucose level every 3 to 4 hours.

84.   Answer: D
The nurse should advise the mother to allow the child to go trick-or-treating. Children need to be treated like their peers. Sheltering them from all temptation does not allow them the opportunity to develop coping strategies for dealing with the restraints made necessary by their disease.

A. Eating sweets can result in hyperglycemia. Although not desired, hyperglycemia is not life-threatening in this context. 

B. Trust between the parent and child is essential in managing this disease. Telling the mother that she must go with her child and watch her would not promote trust. 

C. It would not be advisable to give extra insulin because this action could result in severe hypoglycemia, especially if this usually compliant child remains faithful to the treatment regimen. 

85.   Answer: D
Fosamax is used to treat osteoporosis in post-menopausal women. The patient should be instructed to remain upright for 30 minutes after taking the dose of Fosamax to prevent esophageal irritation. Gastrointestinal side effects of Fosamax include anorexia, abdominal pain, nausea, vomiting, constipation and esophageal ulceration. 

A. Fosamax should be taken in the morning before food is consumed. It should not be crushed and mixed with food. 

B. Fosamax should be taken with six to eight ounces of water. 

C. Fosamax should not be taken sublingually. It should be taken orally with six to eight ounces of water in the morning before food and other medications.

86.   Answer: B
In the client with diabetic ketoacidosis, the nurse would expect to note blood glucose levels between 350 and 1500 mg/dL, ketonuria, venous blood pH between 6.8 and 7.2, and a serum bicarbonate less than 9 mEq/dL. The serum potassium results would be inversely proportional to the pH.

87.   Answer: B
Infection is a physiological stressor that can cause an increase in the level of epinephrine in the body. An increase in epinephrine causes an increase in blood glucose levels. When the client is under stress, such as when an infection exists, the client will require an increase in the dose of insulin to facilitate the transport of excess glucose into the cells. The client would not necessarily need an adjustment in the daily diet. 

88.   Answer: C
With congenital hypothyroidism, failure of normal development occurs during the embryonic period or when an inborn error of metabolism prevents the normal synthesis of thyroxine. Although the condition is present at birth, maternal thyroxine can pass through the placenta to the fetus, supplying the fetus and neonate sufficiently. Thus, in most neonates, the signs of hypothyroidism are commonly masked at birth.

A. Telling the mother that she didn't bring the child in for 2 weeks implies that the mother was at fault, possibly causing the mother to become defensive. 

B. With congenital hypothyroidism, failure of normal development occurs during the embryonic period or when an inborn error of metabolism prevents the normal synthesis of thyroxine. Although the condition is present at birth, maternal thyroxine can pass through the placenta to the fetus, supplying the fetus and neonate sufficiently. Thus, in most neonates, the signs of hypothyroidism are commonly masked at birth. 

 D. Telling the mother that she couldn't be reached is not therapeutic and may cause the mother to become defensive, implying that she was at fault.


89.   Answer: B
Thyrotoxicosis usually occurs in clients with Grave’s disease with the symptoms precipitated by a major stressor. This complication typically occurs during periods of severe physiological or psychological stress such as trauma, sepsis, delivery, or major surgery. Grave’s disease also must be recognized as a potential complication following thyroidectomy.

90.  Answer: C
Insulin should not be frozen. If the nurse notes that the vial of insulin is frozen, the nurse should discard the insulin and obtain a new vial. Options A, B, and D are incorrect actions.

91.   Answer: C
Metformin should be used with caution in clients with kidney or liver disease, heart failure, chronic lung disease, and a history of heavy alcohol consumption. Options A, B, and D are not associated caution of contraindications in the use of this medication.

92.   Answer: D
Standard measures to lower body temperature include removing bed covers, providing cool sponge baths, using an electric fan in the room, administering acetaminophen, and placing a hypothermia blanket under the client. Ice packs are avoided because they could cause shivering, which increases cellular oxygen demands and could increase intracranial pressure. If shivering occurs, it is managed with chlorpromazine (Thorazine).

93.  Answer: A
Cushing’s syndrome is a condition caused by excessive amounts of cortisol. Options B, C and D are inaccurate descriptions of this disorder.

94.   Answer: D
Signs and symptoms associated with hypoglycemia include nervousness, diaphoresis, weakness, light-headedness, confusion, paresthesia, irritability, headache, hunger, tachycardia, and changes in speech, hearing, or vision. If untreated, signs and symptoms may progress to unconsciousness, seizures, coma, and death. Polyuria, polyphagia, and polydipsia are symptoms associated with hyperglycemia.

95.  Answer: A
Acarbose delays glucose absorption, so the client should take an oral form of dextrose rather than a product containing table sugar when treating hypoglycemia. The alpha-glucosidase inhibitors work by delaying the carbohydrate digestion and glucose absorption. It's safe to be on a regimen that includes insulin and an alpha-glucosidase inhibitor. The client should take the drug at the start of a meal, not 30 minutes to an hour before.

96.   Answer: B,A,C,D,E
The client is experiencing symptoms of mild hypoglycemia. If symptoms such as hunger, irritability, shakiness, or weakness occur, the nurse first would check the client’s blood glucose level to verify that the client is experiencing hypoglycemia. Once this is verified, the nurse would give the client 10 to 15 g of carbohydrates. The nurse would retest the blood glucose in 15 minutes. In the mean time, the nurse would check the client’s vital signs. The nurse would give the client another 10- to 15-g carbohydrate food item if the client’s symptoms do not resolve. Otherwise, the nurse would provide a small snack of carbohydrates and protein if the client’s next scheduled meal is more than an hour away from the time of the occurrence. Following the treatment and resolution of the hypoglycemic event, the nurse would document the occurrence, actions taken, and outcome.

97.   Answer: A
Glipizide begins to act in 15 to 30 minutes. The other options are incorrect.

98.   Answer: D
The client with Cushing’s syndrome should be reassured that most physical changes resolve with treatment. Options A, B, and C are not therapeutic responses.

99.   Answer: D
The nurse informs the client that the test aids in determining whether symptoms are caused by abnormalities in the adrenal gland. The nurse assesses the client for allergies to iodine before the test. The nurse tells the client that the client may experience a transient burning sensation after the dye is injected, that the client will be placed in a supine position, and that the insertion site will be anesthetized locally. An informed consent form is required.

100. Answer: B
Myxedema is a deficiency of thyroid hormone. The client has a puffy edematous face especially around the eyes, periorbital edema, coarse facial features, dry skin, and dry, coarse hair and eyebrows. Options A, C, and D are noted in the client with hyperthyroidism.

101. Answer: D
Serum osmolarity is the most important test for confirming HHNS; it's also used to guide treatment strategies and determine evaluation criteria. A client with HHNS typically has a serum osmolarity of more than 350 mOsm/L. Serum potassium, serum sodium, and ABG values are also measured, but they aren't as important as serum osmolarity for confirming a diagnosis of HHNS. A client with HHNS typically has hypernatremia and osmotic diuresis. ABG values reveal acidosis, and the potassium level is variable.

102. Answer: B
Special foods are not required for a client with diabetes, nor should certain foods (except refined sugars) be eliminated entirely from the diet. More important is that meal times, meal size, and meal composition are consistent. Pasta may be included in the diet as part of the bread and cereal exchange. 

A. Pasta can be included in the client's diet as long as it is counted in the exchanges. 

C. Pasta sauces may be used if they are taken into account in the total diet. 

D. A client's ethnic, religious, and cultural food preferences should be taken into account in meal planning. If these preferences are not considered, a client may eat foods without making proper adjustments or may reject the diet entirely. As long as the pasta is counted in the exchanges, it will not necessarily cause hyperglycemia. 

103. Answer: C
An enlarged thyroid gland occurs in a client with goiter because an excessive amount of thyroxine occurs in the thyroid gland, causing it to enlarge. Slow wound healing can occur with zinc deficiency. Heart damage can occur with selenium deficiency. Additionally, heart damage would not likely be noted during the nursing assessment. Further diagnostic tests, in addition to assessment, would be necessary to determine heart damage.

104. Answer: C
Hashimoto's thyroiditis, an autoimmune disorder, is the most common cause of hypothyroidism. It's seen most frequently in women over age 40. Weight gain, decreased appetite, constipation, lethargy, dry cool skin, brittle nails, coarse hair, muscle cramps, weakness, and sleep apnea are symptoms of Hashimoto's thyroiditis. Weight loss, increased appetite, and hyperdefecation are characteristic of hyperthyroidism. Weight loss, increased urination, and increased thirst are characteristic of uncontrolled diabetes mellitus. Weight gain, increased urination, and purplish-red striae are characteristic of hypercortisolism.

105. Answer: A
Common manifestations of Addison’s disease include postural hypotension from fluid loss, syncope, and muscle weakness. Anorexia, nausea and vomiting, abdominal cramps, weight loss, depression, and irritability. Options B, C, and D do not occur with this disease.

106. Answer: D
After computed tomography scanning, the client may resume all usual activities. The client should be encouraged to consume extra fluids to replace those lost with diuresis form the contrast dye.

107. Answer: A
Because diabetes insipidus results from decreased antidiuretic hormone (vasopressin) production, the nurse should expect hormone replacement therapy with synthetic vasopressin. The diuretic furosemide is contraindicated because the client is experiencing polyuria. Insulin and dextrose are used to treat diabetes mellitus and its complications — not diabetes insipidus. 

108.  Answer: D
A triad clinical symptoms including excessive thirst, Polydipsia, and polyuria often occurs suddenly in the client with diabetes insipidus. The urine is dilute with a specific gravity less than 1.006, and the serum osmolality is increased beyond 280 mOsm/L. (SR 7604)

109. Answer: C
A GTT indicates a diagnosis of diabetes mellitus when the 2-hour blood glucose level is greater than 200 mg/dl. Confirmation occurs when at least one subsequent result is greater than 200 mg/dl.

110. Answer: A
Clients with Addison's disease and their family members should know how to administer I.M. hydrocortisone during periods of stress. It's important to keep well hydrated during stress, but the critical component in this situation is to know how and when to use I.M. hydrocortisone. Capillary blood glucose monitoring isn't indicated in this situation because the client doesn't have diabetes mellitus. Hydrocortisone replacement doesn't cause insulin resistance.

111. Answer: C
Asymptomatic proteinuria is an initial sign of diabetic nephropathy. Microscopic proteinuria should be monitored yearly in all clients with diabetes for over 5 years. 

A. Polyuria is a symptom of poorly managed diabetes. 

B. Ketonuria is a sign of diabetic ketoacidosis. 

D. Increasing glycosuria is a symptom of poorly managed diabetes.

112. Answer: A
Classic signs of water intoxication include confusion and seizures, both of which are caused by cerebral edema. Weight gain will also occur. Sunken eyeballs, thirst, and increased BUN levels indicate fluid volume deficit. Spasticity, flaccidity, and tetany are unrelated to water intoxication.

113. Answer: A
A moderate exercise program will help strengthen bones and prevent the bone loss that occurs from excess parathyroid hormone. Walking or swimming provides the most beneficial exercise. Weight loss might be beneficial but it isn't as important as developing a moderate exercise program. Because of weakened bones, a rigorous exercise program such as jogging would be contraindicated.

114. Answer: A
Lack (absolute or relative) of insulin is the primary cause of DKA. Treatment consists of insulin administration (normal saline initially), and potassium replacement, followed by correcting acidosis. Applying and electrocardiogram monitor is not a priority action.

115. Answer: A
Excessive dosing with propylthiouracil may convert the client from a hyperthyroid state to a hypothyroid state. If this occurs, the dosage should be reduced. Temporary administration of thyroid hormone may be required. Propylthiouracil is not used for pain and does not cause hyperglycemia or renal toxicity.

116. Answer: A
Manifestations of hypothyroidism include cold intolerance, constipation, loss of initiative, thick dry skin, weight gain, a notably puffy appearance of the skin around the eyes, slowed intellectual function, including retarded speech and apathy, and low metabolic rate. Levothyroxine (Synthroid) is used to correct hypothyroidism. The dosage needs to be increased.

117. Answer: D
Because respirations are depressed in myxedema coma, maintaining a patent airway is the most critical nursing intervention. Ventilatory support is usually needed. Thyroid replacement will be administered I.V. Although myxedema coma is associated with severe hypothermia, a warming blanket shouldn't be used because it may cause vasodilation and shock. Gradual warming with blankets would be appropriate. Intake and output are very important but aren't critical interventions at this time.

118. Answer: A
Diabetes insipidus is characterized by polyuria (up to 8 L/day), constant thirst, and an unusually high oral intake of fluids. Treatment with the appropriate drug should decrease urine output and oral fluid intake. A urine output of 200 ml/hour indicates continuing polyuria. Blood pressure at 90/50 mm Hg and a pulse rate of 126 beats/minute are signs of compensation for continued fluid deficit, suggesting that treatment hasn't been effective.

119. Answer: B
The suggested treatment of hypoglycemia in a conscious client is a simple sugar (such as two packets of sugar), followed by a complex CHO (such as a slice of bread), and lastly a protein (such as milk); the simple sugar elevates the blood glucose level rapidly; the complex CHO and protein produce a more sustained response. 

A. These are fast-acting sugars, and neither of them will provide a sustained response.

C. The fat content of chocolate candy decreases the rate of absorption of glucose. 

D. Neither of these are fast-acting sugars; peanut butter crackers and milk can be used to maintain the glucose level after it has been raised. 

120. Answer: B
Spironolactone can cause menstrual irregularities and decreased libido. Men may also experience gynecomastia and impotence. Breast tenderness, increased facial hair, and hair loss aren't associated with spironolactone.

121. Answer: A
The client with liver disease has a decreased ability to metabolize CHO because of a decreased ability to form glycogen (glycogenesis) and to form glucose from glycogen (glycogenolysis). 

B. Hypertension is not related to a decreased serum glucose level.

C. Clients with Type 2 diabetes do not depend on exogenous insulin, nor are they prone to ketosis; the blood glucose levels fall much more slowly, and there is ample time to monitor signs and symptoms before insulin shock can develop.

D. Hyperthyroidism is not related to a decreased serum glucose level.

122. Answer: D
Exercise increases the use of blood glucose by the muscles, therefore reducing the body's insulin requirements. Exercise also tends to lower blood cholesterol and triglyceride levels. In addition, exercise is a healthful diversionary activity, helps control weight, and promotes circulation. 

A. Exercise can precipitate an episode of hypoglycemia if carbohydrates are not replaced. 

B. Exercise does not stimulate overproduction of insulin; it increases carbohydrate metabolism which, for the diabetic, can result in hypoglycemia. 

C. Exercise does not affect the renal threshold for glucose.

123. Answer: C
Regular follow-up care for the client with Graves' disease is critical because most cases eventually result in hypothyroidism. Annual thyroid-stimulating hormone tests and the client's ability to recognize signs and symptoms of thyroid dysfunction will help detect thyroid abnormalities early. Intake and output is important for clients with fluid and electrolyte imbalances but not thyroid disorders. DDAVP is used to treat diabetes insipidus. While exercise to improve cardiovascular fitness is important, for this client the importance of regular follow-up is most critical.

124. Answer: C
These are the classic signs associated with hyperthyroidism; weight loss and restlessness occur because of an increased basal metabolic rate; exophthalmos occurs because of peribulbar edema.

A. These are all associated with hypothyroidism because of the decreased metabolic rate. 

B. Lethargy and weight gain are associated with hypothyroidism as a result of a decreased metabolic rate; forgetfulness is not related. 

D. Although weight loss and exophthalmos occur with hyperthyroidism, the client would be hyperactive, not hypoactive.

125. Answer: A
Muscle weakness, bradycardia, nausea, diarrhea, and paresthesia of the hands, feet, tongue, and face are findings associated with hyperkalemia, which is transient and occurs from transient hypoaldosteronism when the adenoma is removed. Tremors, diaphoresis, and constipation aren't seen in hyperkalemia.

126. Answer: B
After a subtotal thyroidectomy, swelling of the surgical site (the tracheal area) may obstruct the airway. For this reason, the nurse should keep a tracheostomy set at the client's bedside in case of respiratory emergency. Although an indwelling urinary catheter and cardiac monitor may be used for a client after a thyroidectomy, the tracheostomy set is most important. A humidifier isn't indicated for this client.

127. Answer: C
The nurse must emphasize to the client and family that they are not eating a diabetic diet but rather a balanced meal plan. Adherence to nutrition principles is an important component of diabetic management, and an individualized meal plan should be developed for the client. The client does not need to purchase dietetic foods.

128. Answer: B
The accumulation of ketones, organic acids that readily release free hydrogen ions causing blood pH to fall, leads to ketoacidosis. To compensate, the respiratory buffering system is activated, which results in the child taking deep, rapid breaths to rid the body of excess carbon dioxide. This characteristic breathing pattern is known as Kussmaul's respirations. 

A. Typically with ketoacidosis, the pulse rate would be more rapid and weak due to dehydration and loss of electrolytes. 

C. Typically with ketoacidosis, the skin will be dry due to dehydration. 

D. With ketoacidosis, hypotension results from the contracted blood volume secondary to dehydration.

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